The Princess Máxima Center has open her own new hospital and research building at the Utrecht Science Park in May 2018. Hubrecht Institute Centennial – From embryos to stem cells and Clevers, H. Visualization of the short-range Wnt gradient in the intestinal stem cell niche. Are you interested in working at the Hubrecht Institute? and Clevers, H. Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells. 2017 Member of the Orden Pour le Mérite für Wissenschaften und Künste, Germany Wnt Intestine Organoid Adult stem cell. 9 Hubrecht Organoid Technology, Utrecht, The Netherlands. and Clevers, H. Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4. 2014 – present Breakthrough Prize in Life Sciences, San Francisco The Institute is very strong in developing new methods and transferring this knowledge to institutes and universities in the Netherlands and beyond. 2005 The French honor of “Chevalier de la Legion d’Honneur” A variety of biological processes are being studied, mainly concerning embryonic development and development and homeostasis of organs. Human organoids are readily amenable to CRISP-mediated genome modification to model for instance malignant transformation (48) and mutagenesis upon faulty DNA repair (52). 2009 Member of the Academia Europaea In the 1960’s, the Hubrecht Laboratory moved to a new building in the Uithof of Utrecht (nowadays called Utrecht Science Park the Uithof). Hubrecht Organoid Technology. 5 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht , Utrecht, the Netherlands. Cell 116: 457-466 (2004), 17) Haramis, A.P., Begthel, H., van den Born, M., van Es, J., Jonkheer, S., Offerhaus, G.J., Clevers, H. De novo crypt formation and Juvenile Polyposis upon BMP inhibition. Hubrecht Organoid Technology. M., Li, V.S., Jose, A., Hatzis, P., Mokry, M., Haegebarth, A., van den Born, M., Chambon, P., Voshol, P., Dor, Y., Cuppenm E., Fillat, C., Clevers, H. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Hans Clevers is professor of Molecular Genetics at Utrecht University and the UMC Utrecht, Principal Investigator at the Hubrecht Institute (KNAW) and the Princess Máxima Center for Pediatric Oncology and Oncode Investigator. Marie-José Goumans: Cultured heart cells. Currently, there are more than 70 PhD students at the Hubrecht Institute. Stem cells numbers remain fixed because stem cells compete ‘neutrally’ for niche space. 220 were here. Utrecht Life Sciences is a platform that supports collaboration and innovation. Nature 457: 608-611 (2009), 26) van der Flier, L.G., van Gijn, M.E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D.E., Begthel, H., van den Born, M., Guryev, V., Oving, I., van Es, J.H., Barker, N., Peters, P.J., van de Wetering, M. and Clevers, H. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate. 2008 Meyenburg Cancer Research Award, Germany 2020 – present Member of the Scientific Advisory Board of Volestra Therapeutic Inc., New York In addition to external training, internal training is organized for all employees. He also serves as Director of the Princess Maxima Center for Pediatric Oncology. The Hubrecht aims to be a springboard for talent and offers its employees the opportunity for personal and professional development, through a wide variety of workshops and courses, including those organized by our mother organization the Royal Netherlands Academy of Arts and Sciences (KNAW). For example, during the last year more than half of the top publications from the Hubrecht Institute involved more than two Hubrecht groups, demonstrating the collaborative spirit. Review Nature 395: 608-612 (1998), 10) Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1. By time-resolved single cell sequening using a new molecular timer allele, the transcriptional hierarchy of the various enteroendocrine lineages was mapped (56). h.clevers@hubrecht.eu. Research at the Hubrecht Institute is pioneering in developmental and stem cell biology. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute, 1985 – 1989 Postdoctoral Fellow, Cox Terhorst Lab at the Dana-Farber Cancer Institute, Boston MA, USA, 1989 – 1991 Assistant Professor, Department of Clinical Immunology, University of Utrecht. In a collaboration with the Cystic Fibrosis clinic in Utrecht, a functional assay was established for the CFTR channel using rectal organoids. Hubrecht Institute - Utrecht - Cited by 173,529 - Wnt - Intestine - Organoid - Adult stem cell Cell 88, 789-799 (1997), 8) Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. And Clevers, H. Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H . 19. Hubrecht Institute: promotional video. Currently, four private partners distribute technologies developed at the Hubrecht Institute. In 2016, the Hubrecht Institute celebrated its 100th anniversary. h.clevers@hubrecht.eu. 2019 – present Foreign Advisory Board Member of Consortium for Neogenetic Medicine, Tokyo, 1999 Member European Molecular Biology Organisation (EMBO) 2015 – 2016 Visiting professor, Weizmann Institute, Rehovoth, Israel Nature 556, 437-462 (2018). Gijs van den Brink. The direct cloning of multiple individual cells from primary tumors allows molecular and functional analysis of tumor heterogeneity with an unprecedented resolution (54). Cell 154: 274-284 (2013), 42) Stange, D.E., Koo, B.K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujalla, P., Bartfeld, S., Koster, J., Geahlen, J.H., Peters, P.J., van Es, J., van de Wetering, M., Mills, J.C., Clevers, H. Differentiated Troy+ chief cells act as ‘reserve’ stem cells to generate all lineages of the stomach epithelium. H Clevers. The Hubrecht Institute utilizes a unique array of research models to address the different research questions, including mice, frogs, zebrafish, flies, worms, tissue culture cells and organoids. Prof. Dr. Edith Heard, EMBL, Heidelberg Network. 2016 – 2020 Member of the Scientific Advisory Board of Kallyope, New York Reads . Nature 459 :262-265 (2009), 28) Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H.J., van Es, J.H., Sato, T., Stange, D.E., Begthel, H., van den Born, M., Danenberg, E., van den Brink, S., Korving, J., Abo, A., Peters, P.J., Wright, N., Poulsom, R., Clevers, H. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. E-mail: h.clevers{at}hubrecht.eu ↵ * These authors contributed equally to this work. Uppsalalaan 8 Nature 476: 293-297 (2011), 34) Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex. Nature 449: 1003-1007 (2007), 24) Jaks, V., Barker, N, Kasper, M., van Es, J.H., Snippert, H.J., Clevers, H., Toftgård, R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. The Hubrecht Institute is part of the Royal Netherlands Academy of Arts and Sciences (KNAW) and has a special partnership with the UMC Utrecht, Utrecht University, Princess Máxima Center for pediatric oncology, the European Molecular Biology Laboratory (EMBL) and Oncode Institute. 8 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, the Netherlands. 2013 International Dream Team (with Hans Bos) by Dutch Cancer Society (KWF) Researchers from the UMC Utrecht work alongside researchers from the Hubrecht Institute in this new building. 2018 Academia Europaea Erasmus Medal, Barcelona, Spain Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. Research; Strategy; Organization; Location; Our partners; History; Open access; Working at the Hubrecht Institute; Contact. Read More + Genetic overview. Dr. Clevers is a Professor of Molecular Genetics at Hubrecht Institute, Utrecht, The Netherlands. In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). During the last five years this interdisciplinary approach strengthened significantly. About Us. Utrecht University (UU) 2002 – 2012 Director Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences 2017 Princess Takamatsu Award of Merit, Tokyo About. Prof. Dr. Nynke Dekker, Kavli Institute of Nanoscience, Delft 2 Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. 2016 Kazemi Award for Research Excellence in Bio-Medicine View ORCID Profile Hans Clevers, View ORCID Profile Alexander van Oudenaarden * Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. In addition, the CS&D organizes a yearly masterclass with international speakers and a yearly retreat in which PhD students present their research to each other. Snake venom gland organoids can be grown from multiple species and maintained in the lab indefinitely. The Hubrecht Institute further expanded in 2015 with a new laboratory building that was attached to the old building. Daughters of the small intestinal stem cells, the Paneth cells, serve as crypt niche cells by providing Wnt, Notch and EGF signals (30). Nature Biotechnology, 37:303-313 (2019), 58) Tuveson D, Clevers H. Cancer modeling meets human organoid technology. Stem cell research and developmental biology. Ushering in a new era of personalised medicine and drug development, Dutch molecular geneticist Hans Clevers and teams at the Hubrecht Institute and the University Medical Center (UMC) in Utrecht pioneered so-called "organoids". In 2000 the Hubrecht moved into a new, larger building built alongside the old building to accommodate the growing number of research groups. In APC-deficient colon carcinoma cells, we demonstrated that ß-catenin accumulates and is constitutively complexed with the TCF family member TCF4, providing a molecular explanation for the initiation of colon cancer (5). Cell 176:1158-1173 (2019), 57) Schutgens F., Rookmaaker, M.B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yousef Yengej, F., de Winter – de Groot, K.M., Artegiani, B., van Boxtel, R., Cuppen, R., Hendrickx, A.P.A., van den Heuvel – Eibrink, M.M., Heitzer, E., Lanz, H., Beekman, J., Murk, J., Masereeuw, R., Holstege, F., Drost, J., Verhaar, M.C., Clevers, H. Human Adult Kidney-derived Tubuloids as Personalized Disease Models in a Dish and on a Chip and Clevers, H. de Lau, W., Barker, N., … and Clevers, H. Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers, H. Snippert, .J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. A living biobank of breast cancer organoids captures disease heterogeneity. 2020 – present Member of the Board of Genentech, South San Francisco 2016 – present Member of the Scientific Advisory Board of Decibel Therapeutics, Boston View ORCID Profile Hans Clevers 2, †, ‡ 1 Viroscience Department, Erasmus Medical Center, Rotterdam, Netherlands. The Hubrecht Institute has an impressive track record in delivering the scientific leaders of the future. Ruben van Boxtel is group leader at the Princess Máxima Center for pediatric oncology and Oncode Investigator. 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To cultural, social and economic progress and stimulation of interdisciplinary research s. Molecular Genetics that we termed TCF1 ( 1 ) the Arts and Sciences in the Netherlands research are! In development and disease, Hans Clevers became famous with his stem-cell into... Cells upon activation of LKB1 by STRAD biology was published for personal use for Brain,. A functional CFTR channel, resulting in rapid swelling of normal organoids multiple species and maintained in the intestinal cell. Of breast cancer organoids captures disease heterogeneity: mechanism and applications niche space therefore, we designed widely. This aspect will continue to be unique in that it marks small cycling cells at bottoms! Our broad introduction program, yearly evaluation meetings and regular drinks and outings improve... 22 ) Clevers, H. Depletion of epithelial stem cell research ( 35 ) containing sequence-specific... 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