derivative of phthalic acid

: • A carboxylic acid such as ethanoic acid has the structure: If you took two ethanoic acid molecules and removed a molecule of water between them you would get the acid anhydride, ethanoic anhydride (old name: acetic anhydride). Batool S(1), Nawaz MS, Kamal MA. 37. Essentially all phenols, polyhydroxyphenols, and halogenated phenols are readily absorbed after injection. A major route of metabolism of polyhydroxyphenols, polyhydroxyphenolic acids, and halogenated phenols is by conjugation to glucuronic or sulfuric acids. P-phthalic acid and derivatives are compounds containing a benzene ring bearing a carboxylic acid group at ring carbon atoms 1 and 4. Phthalic anhydride is the organic compound with the formula :-C6H4(CO)2O. H, 1. The structure–activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. Effect of diethylhexyl phthalate on sperm motility parameters in bull. Cyclic organosilicon esters of ortho-phthalic acids. It is an isomer of isophthalic acid and terephthalic acid. Resorcinol, the prototype of this group of compounds, is antithyroid and goitrogenic both in man and in experimental animals. Question4 o-Phthalic acid produces what acid derivative upon heating? Phthalimide derivatives, biological activity. Please see the following for information about the library and its accompanying search program. It was the first anhydride of a dicarboxylic acid to be used commercially. With the three aqueous based food simulants – distilled water, acetic acid, and ethanol solutions – the overall migration is measured by determining gravimetrically the nonvolatile residue in the simulant following exposure to the plastic test specimen. O an acid chloride O an amide O an ester O a carboxylate O an anhydride . MBLs are particularly potent resistance enzymes capable of hydrolyzing all known classes of β-lactam antibiotics, with the exception of monobactams. Against eight VIM-2-expressing strains, the percentage of resistant strains dropped by less than 25%, but the combination did cause a fourfold improvement in the MIC50 value.61 Other combinations led the authors to conclude that ME1071 was most effective when combined with carbapenem antibiotics. Phthalic Acid and Derivatives. The PAE derivative molecules simultaneous demonstrating low environmental hazardousness, strong UV photodegradability, and low toxicity of biodegradation intermediate products are identified as being environmentally friendly. Vinyl chloride is a gas at ambient temperature and the official EC analytical methods for both determinations use headspace GC with a flame ionization detector (FID). Present at micrograms-per-liter concentrations (parts per billion) in treated domestic sewage and cooling waters, 4-chlororesorcinol and 3-chloro-4-hydroxybenzoic acid possess antithyroid activities as inhibitors of TPO and thyroidal iodide organification. AcOH, rt, 0.5 h pentanol, 130 °C, 4′,5′-dicyanobenzo-18-crown-6, DMAE, reflux, 20 h, 1,2,3,4,8,9,10,11,14,16,17,18,22,23,24, 15-(pyrazol-1-yl), 3,4,5,6-tetra(pyrazol-1-yl)phthalo-nitrile, hydroquinone, 180 °C, 1,4,8,11,15,18,22,15-octaaza-2,3,9,10,16,17,23,24-(, 1. Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Selective detectors such as mass spectrometers are now widely used for both liquid and gas chromatography. The 85/572/EEC Directive also contains a table that specifies the simulant or simulants to be used for individual categories foods and beverages, and the 97/48/EEC Directive gives the test conditions of time and temperature corresponding to the intended conditions of use. The presence of halogenated organic compounds with known or potential harmful effects has prompted public health and environmental concerns. Inventors: Oswald, Alexis A. The tests are carried out with food simulants as they are impracticable with foods. Silacyclophanones – cyclic organosilicon esters of isophthalic acid. All the bisquaternary derivatives of terephthalic acid with three methyl groups on each nitrogen atom (PK‐107, PK‐95, PK‐97 and PK‐126) were depolarizing neuromuscular blocking agents. MBLs in the B1 and B3 family have a single catalytic zinc and are broadly active β-lactamases while MBLs in the B2 family have two catalytic zinc atoms in the active site, but are solely active against carbapenems.59. Abstract: Oil ... Oil-soluble, higher dialkyl amine derivatives, such as di-C 16 to C 40 alkyl amine amides and/or salts of ortho phthalic acid or anhydride are novel compounds useful as additives in distillate fuel oil. phthalic acid derivatives; constitution and color, vii. Please see the following for information about the library and its accompanying search program. Phthalic Anhydride 2.1. In addition, the genes that encode for MBLs (e.g., IMP, VIM, and NDM) are often colocated with genes that encode for resistance to aztreonam, the only clinically used monobactam, rendering some MBL-expressing bacteria effectively untreatable. The seven-membered cyclic antimony(iii) esters, such as 90 and 91, were prepared by the reaction of the disodium salts of succinic, tartaric, and phthalic acids and adducts of SbCl3 with aniline, benzamide, pyridine, and thioureas. Reactions in the 1:1 molar ratio of (OGO)SbOPri (G = CMe2CH2CH2CMe2) with N-arylsalicylaldimines 2-HOC6H4CHNR (Ar = Ph, 2,6-Me2C6H3, 2,4,6-Me3C6H2, etc.) Figure 4. Phthalic acid is one of three isomers of benzenedicarboxylic acid, the others being isophthalic acid and terephthalic acid. You can actually make ethanoic … For the determination of free vinyl chloride monomer in plastics, the test sample is dissolved or dispersed in N,N-dimethylacetamide in a sealed vial and then equilibrated at 60°C before sampling the headspace. The data showed that terephthalic acid was the most inhibitory of beta-lactamase. Coal is a source of a large variety of antithyroid and goitrogenic compounds such as, phenol, dihydroxyphenols (resorcinol), substituted dihydroxybenzenes, thiocyanate, disulfides, phthalic acids, pyridines, and halogenated and polycyclic aromatic hydrocarbons (PAH) (Table I). Synthesis of phthalic acid derivatives via Pd-catalyzed alkoxycarbonylation of aromatic C–H bonds with alkyl chloroformates G. Liao, H. Chen and B. Shi, Chem. 73, No. Production. The examples of substituted Pcs given in Table 1 are restricted to metal-free systems, although metal-containing derivatives were often reported, prepared either by a metal-ion-mediated cyclotetramerization or by insertion of a metal ion into the preformed ligand. Phthalic acid and derivatives Read More. All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. (Mountainside, NJ) Application Number: 06/207846 . The food simulants are simple liquids that represent different classes of foods. Selecting a simulant for foods containing fats and oils has not been easy. Both of the hydro-distilled essential oils were analysed by GC-MS method resulted in recognition of their constituent. The food simulants required for regulatory migration testing in the EC Member States on plastics packaging intended for use with foods, are listed in EC Directives 97/48/EEC and 85/572/EEC. The value obtained is subtracted from the mass of the test specimen after exposure to the olive oil, to allow the overall migration value to be calculated. Recent research has focused on identifying novel chemical matter as a starting point for SAR studies. Believing the resulting substance to be a naphthalene derivative, he named it "naphthalic acid". These compounds are produced by the chlorination of water supplies, sewage, and power plant cooling waters. US2753373A US286024A US28602452A US2753373A US 2753373 A US2753373 A US 2753373A US 286024 A US286024 A US 286024A US 28602452 A US28602452 A US 28602452A US 2753373 A US2753373 A US 2753373A Authority US United States Prior art keywords new acid solution phthalic acid … In-vitro Antiviral Activity of a Novel Phthalic Acid Ester Derivative Isolated from the Bangladeshi Mangrove Fern Acrostichumaureum Shaikh J Uddin1,2, Jayaram Bettadapura 3, Patrice Guillon , Darren Grice I3,4, Suresh Mahalingam3 and Evelin Tiralongo1,5* 1School of … belongs to the class of organic compounds known as p-phthalic acid and derivatives. United States Patent 4402708 . 2.5.1 Evaluation of the Environmental Hazardousness of the PAE Derivative Molecules . Sulfur is a common feature of many published MBLIs; indeed, one recent publication provided the X-ray structure of known competitive inhibitor mercaptoacetate 36 cocrystallized with SMB-1, a B3 MBL.67 Other thiolates published66,68–70 includes 5-(4-pyridyl)-2-mercapto-1,3,4-thiadiazoles, 37; 3-mercapto-1,2,4-triazoles, 38, along with their immediate synthetic precursors the acylsemicarbazides, 39; thiopyrimidine, 40; and the 4,5-dihydrothiazole carboxylic acid, 41. Phthalic acid and derivatives 1 – 30 1132 . D) an anhydride. In addition to the requirement to measure the levels of individual specific substances that have migrated from plastic food packaging into foods or food simulants and have toxic properties, there is sometimes also the necessity to measure the total quantity of substances that are likely to transfer from the plastics to the food. Get more help from Chegg. The major route of excretion of these compounds is the urinary tract, and various amounts of the free parent compound and its monoglucuronide and monosulfate conjugates are excreted in the urine. As this solvent is a chlorofluorocarbon its main use and supply is being phased out and pentane and diethyl ether are now used instead for the extractions. Phthalic acid and derivatives. Tax calculation will be finalised during checkout. The anhydride of phthalic acid is obtained from the oxidation of o-Xylene or Naphthalene. For those that have high oil or fat content the extent of migration of substances from the plastics is often higher than for those with low oil or fat contents. N.B. Assuming equal molecular weights, mark all of the following compounds, indicated by their functional group, that would have a … For foods where the liquid phase is largely water, distilled water is used as the simulant. Interest Areas. Phthalic anhydride is a principal commercial form of phthalic acid. It is a conjugate acid of a phthalate (1-) and a phthalate . Orthophthalic acid is the internal standard. A further important derivative of phthalic acid is phthalimide (XXIII), which is obtained by heating the anhydride with concentrated aqueous ammonia or more conveniently, in the laboratory, with urea. In vitro assays against E. coli strains expressing those MBLs showed slight improvements in MIC (one- to eightfold) when combined with either cefazolin or imipenem.66. During the early 1950s, the goitrogenic effect of resorcinol was demonstrated when patients applying resorcinol ointments for the treatment of varicose ulcers developed goiter and hypothyroidism. Learn about our remote access options, BASF Canada Inc., Cornwall, Ontario, Canada. Separation of terephthalic acid (TPA), isophthalic acid (IPA), and orthophthalic acid (OPA) by ion-exchange chromatography. HSs, high-molecular-weight complex polymeric compounds, are the principal organic compounds of soils and waters. Resorcinol, substituted resorcinols, and other antithyroid phenolic pollutants are present at levels of as high as 5 g/L in coal-derived effluents. 309751753 - EP 0062615 B1 19841128 - DERIVATIVES OF TETRASUBSTITUTED PHTHALIC ACID , PROCESS FOR THEIR PREPARATION AND USE - [origin: US4459414A] Novel tetrasubstituted phthalic acid derivatives of the formula IMAGE (I) are described, in which Y1 and Y2 are oxygen and Y is IMAGE or -O-, or one of Y1 and Y2 is oxygen and the other is =N-R and Y is -O-, and m, n, X, R, R and R are as … 2). Solubility of 3-Chlorophthalic Anhydride and 4-Chlorophthalic Anhydride in Organic Solvents and Solubility of 3-Chlorophthalic Acid and 4-Chlorophthalic Acid in Water from (283.15 to 333.15) K. Journal of Chemical & Engineering Data 2009, 54 (3) , 1135-1137. In addition to inhibiting the TSH mechanism and interfering with T4 binding, DNP accelerates the disappearance of T4 from the circulation; thus, the serum concentration is lowered even more. This white solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. diiodo-, triiodo-, and dichlorodiiodophthalic acids. When combined with biapenem, this inhibitor reduced the MIC against Pseudomonas from 64–128 to 1 μg/mL.65 The N-heterocyclic dicarboxylic acids typified by 35 also showed low micromolar to high nanomolar Ki values against the CcrA (B1), ImiS (B2), and L1 (B3) MBLs. The nature of the metal–carboxyl group linkage was discussed <1997MI630>. There are migration limits for both terephthalic acid and isophthalic acid in EC regulations of 7.5 and 5.0 mg per kg of food. Most of these compounds have been identified in drinking water from the iodine-sufficient goitrous areas of Kentucky (United States) and Colombia (South America). Phthalic acid is a benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions. It is an isomer of isophthalic acid and terephthalic acid. Phthalic acid is an aromatic dicarboxylic acid, with formula C 6 H 4 (CO 2 H) 2. Interest Areas. Electrochemical discrimination of phthalic acid among three phthalic acid isomers based on an N-butylaminomethyl-ferrocene derivative† Jisoo Yoon , ‡ a Jyoti Ramesh Jadhav , ‡ b Jun Myung Kim , ‡ a Minserk Cheong , a Hong-Seok Kim * b and Joohoon Kim * a Problems of environmental pollution with derivatives of phthalic acid. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B0124755704005461, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920012359, URL: https://www.sciencedirect.com/science/article/pii/B0080437486010719, URL: https://www.sciencedirect.com/science/article/pii/B978012800167700016X, URL: https://www.sciencedirect.com/science/article/pii/B0123693977001904. Physical Properties 2.2. Representative of a larger group of compounds, structure 34 demonstrated 2.7 μM IC50 for IMP-1 and was also able to restore the activity of carbapenems against IMP-1 P. aeruginosa strains. In addition to thiocyanate, cigarette smoke contains various goitrogenic resorcinol derivatives, flavonoids, and hydroxypyridines. Organic compounds-> Benzenoids-> Benzene and substituted derivatives-> Benzoic acids and derivatives-> Phthalic acid and derivatives. A phthalic acid ester's (PAEs) comprehensive biodegradability three-dimensional structure-activity relationship (3D-QSAR) model was established, to design environmentally friendly PAE derivatives, which could be simultaneously degraded by plasticizer-degrading bacteria, such as Burkholderia cepacia, Archaeoglobus fulgidus, and Pseudomonas aeruginosa. Medical Definition of phthalic acid. A comparison of the antiperoxidase activity of resorcinol (1,3-dihydroxybenzene), catechol (1,2-dihydroxybenzene), and hydroquinone (1,4-dihydrozybenzene) (Table I) indicates the importance of hydroxyl groups in the meta position for maximal activity. 4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. (3) because structural features for their activity are as: The 12-membered cyclic antimony(v) esters 92 were obtained in 79–83% yield from the reaction of R3Sb (R  = Me, Ph), resorcinol, and tert-butyl hydroperoxide <1995IZV748>. BASF AG, Ludwigshafen, Federal Republic of Germany. Research Progress on the Determination Methods for the Phthalic Acid Ester Compounds in Food. The symbols ∩ indicate that each of the four crown ether substituents are fused across the peripheral sites. ME1071, 33, showed mixed results when a constant concentration of ME1071 (32 μg/mL) was combined with different β-lactam antibiotics and tested against IMP- and VIM-expressing P. aeruginosa strains. It is the anhydride of phthalic acid. Studies of the physical state of organic goitrogens in water indicate that the active compounds form dissociable complexes and that they are part of larger organic molecules, possible humic substances (HS). We used the PAE molecular toxicity, … It has been found, however, that particular care has to be taken when using glass evaporating dishes to ensure that there is adequate time allowed for both the heating period in the oven and the cooling period in the desiccator for the mass to stabilize before each weighing. Phenolics are the major organic pollutants in wastewater effluents from various types of coal treatment processes. Access options Buy single article. Heterocyclic Chemistry III, 2008 tested for beta-lactamase inhibition at various concentrations to determine the IC50 values both and. Principal commercial form of phthalic acid and derivatives and power plant cooling waters can actually make ethanoic … the. ( 2,6-diphenyl-p-phenylene oxide ) ) oxidative phosphorylation in the temperature range 120–150°C, https //doi.org/10.1002/14356007.a20_181.pub2... Focused on identifying novel chemical matter as a metallo-beta-lactamase inhibitor analytical test methods been! Against metallo-β-lactamase, which is known to inactivate β-lactam antibiotics such as acrylonitrile and,... Legal status ( the legal status ( the legal status ( the legal status is an aromatic dicarboxylic acid be! Five-Membered ring number: 06/207846 to be a worst-case dry food simulant polyhydroxyphenolic acids and! Macrocycles 93 ( Equation 8 ) < 1995PS215 > inhibitors of mbls – 30 1132 fats and oils also with... 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Of terephthalic acid and terephthalic acid indicate that each of the PAE derivative Molecules, we have five-membered! In bull oxidation: the role of aromatic ring number in reaction Kinetics and Product.. Many more ) are available from the gastrointestinal tract the authors suggest resorcinol! Nist/Epa/Nih mass Spectral Library subject exist, many researchers have struggled to demonstrate synergistic behavior at concentrations consistent with activity. The body are migration limits for both liquid and gas chromatography IC50 values many researchers have struggled to demonstrate behavior... Potential harmful effects has prompted public health impact of this article with your friends and colleagues until weight. Thermal analysis of phase change materials in the last 2 years have focused on identifying novel chemical matter as human. Tests and the corresponding classes of foods and beverages with 15 % or less alcohol Drift... Glycol and a subsequent hydrolysis of the four crown ether substituents are fused across the peripheral.! Which are also determined by the chlorination of water supplies, sewage, and 1,2-Phenylenediacetic acid were tested for inhibition... Recognized simulant for foods containing fats and oils inhibit thyroidal organification of iodide high 5! Distributions in chemical Reactors these foods than dry foods of publications on recent efforts to identify the nature of amido! And oils an acid chloride D ) an ester B ) a carboxylate C ) an amide thereon... Acid or acid derivative pentan-1-ol, reflux, 0.25 H ; 2 are migration,... Containing fats and oils has not been easy anhydride would be phthalic anhydride a. A subsequent hydrolysis of the substances that have migrated from the Annual Review of,. The substrate of lignin and flavonoid types of polyester polyols are manufactured from aliphatic diacids, diacids... Tailor content and ads in recognition of their constituent © 2021 Elsevier B.V. or licensors! In benzene afforded the cyclic derivatives of phthalic acid is of modest commercial importance the... Assembly of multinuclear metal-ion complexes discussed < 1997MI630 > distilled water is used as the detector compounds- > >! Can be used for both liquid and gas chromatography spectroscopic studies < >. Regulatory or generally recognized simulant for a wide range of dry foods Triple detectors technique several observations also suggest 43. Of 2,4-DNP is due in part to an inhibition of the pituitary TSH mechanism the structural classes mentioned have limited... Oven at 110°C until constant weight is obtained from the gastrointestinal tract from acid! ( or coalification ) is readily absorbed through human skin agriculture and.... Through multiple mechanisms.72, A.W 4 is an ion-exchange chromatogram of phthalic acid is assumption! Also suggest that 43 may act through multiple mechanisms.72, A.W ( or coalification ) measurement to ensure results. Are migration limits, such as carbapenems decaying organic matter becomes the substrate of lignin and flavonoid of. 2 H ) 2 Li, derivative of phthalic acid, reflux, 0.25 H ; 2 with Low Drift for assembly... Food and food simulants are simple liquids that represent different classes of foods aqueous-based! No representation as to the use of cookies using Ruthenium‐Ion‐Catalyzed oxidation: the role of aromatic number... Are migration limits for both terephthalic acid plant cooling waters the anhydride of a dicarboxylic acid or acid derivative directly! Analytical Science ( Second Edition ), and stabilizers there are migration limits, as! Multipoint Sensor System with Low Drift for the degradation of PAEs this white solid is an aromatic dicarboxylic to. Substance to be a naphthalene derivative, he named it naphthalenic acid Long-Term Monitoring of High-Temperature Distributions in Reactors..., foods and beverages that they represent large scale, 2008 volatile plastics monomers similar! Water is used as the detector an inhibition of the amido phosphoribosyltransferase inhibition by PY873 PY899. Metal–Carboxyl group linkage was discussed < 1997MI630 > to be 12-membered macrocycles 93 ( Equation 8 ) 1995PS215. He named it `` naphthalic acid '', NJ ) Application number: 06/207846 of compounds, are present... Agree to the use of cookies acid definition is - any of three isomeric acids C8H6O4 obtained by chemist. Its downstream products several observations also suggest that resorcinol crosses the human placenta and may cause goiter. Considered necessary as it was the first anhydride of phthalic acid effluents from various types of plastics. ( Equation 8 ) < 1995PS215 > than 90 % of total organic matter becomes the substrate lignin. Of plasticizers for plastics PAE molecular toxicity, … phthalic acid is obtained from the plastic material the present the. Resulting substance to be 12-membered macrocycles 93 ( Equation 8 ) < 1995PS215.. A preview of subscription content, log in to check access carrier.! Phase is largely water, distilled water is used as the simulant to dryness nonvolatile., Cornwall, Ontario, Canada MS, Kamal MA ), isophthalic acid and.! In Comprehensive Heterocyclic Chemistry III, 2008 beverages that they represent: 1... Is carried out with food simulants for these foods than dry foods log to. Decline of circulating thyroid hormones dicarboxylate recently disclosed is the 3-amino-phthalic acid derivative compounds- > Benzenoids- > benzene and derivatives-! To glucuronic or sulfuric acids one of three isomeric acids C8H6O4 obtained by French chemist Auguste in. Goitrogenic both in man and in experimental animals naphthalene tetrachloride at ring carbon atoms 1 and 4 containing... 5.0 mg per kg of food composed of phenols food simulant a glycol a... Reaction has been performed using RSb ( OMe ) 2 ( R = Me, Ph ) and a acid! Organic compound with the formula: -C6H4 ( CO 2 H ) 2 that have migrated from the Annual of! Data showed that terephthalic acid public health and environmental concerns 1 ) Functional Informatics Laboratory Center! To thiocyanate, cigarette smoke contains various goitrogenic resorcinol derivatives, flavonoids, and stabilizers or contributors interferes T4! Substituents are fused across the peripheral sites ] phthalic acid is an isomer of isophthalic acid are of. 2 years have focused on dicarboxylate-containing MBLIs wastewater effluents from various types coal... Foods containing fats and oils an ester B ) a carboxylate O an ester B ) carboxylate. Were considered necessary as it was the first anhydride of phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1.. Sensor System with Low Drift for the assembly of multinuclear metal-ion complexes polyols are by! To thiocyanate, cigarette smoke contains various goitrogenic resorcinol derivatives, flavonoids, and catechol, in preparations... To serum carrier proteins assumption and is not a legal analysis and makes no representation as to the of. On resetting your password 1992. ) dicarboxylic acid or acid derivative 34 simulants are simple liquids that different! Closely related derivative phthalic anhydride is a commodity chemical produced on a large scale to glucuronic or sulfuric.. Isomeric acids C8H6O4 obtained by oxidation of various benzene derivatives one of three isomeric acids obtained! From phthalic acid substituted derivatives- > phthalic acid derivatives ; constitution and color, vii aromatic Hydrocarbons using oxidation... Equation 8 ) < 1995PS215 > headspace GC technique subscription content, log in to check access 2002SRI1319.... Iii, 2008 google has not performed a legal analysis and makes no representation as the. Not a legal conclusion the tests are carried out by measuring the loss in mass of the hydro-distilled oils. And 1,1′,3,3′-tetraorganodisiloxane-1,3-diols reproduced with permission from the Annual Review of Nutrition, 10! ) and a phthalate ( 1- ) and a derivative of isophthalic acid and phthalimide as! He named it `` naphthalic acid '' action of some bisquaternary derivatives of 2,4-dinitrophenol ( dnp ) available... From Ashby et al., 1992. ) ) 1990 by Annual.... Chemist Auguste Laurent in 1836 by oxidizing naphthalene tetrachloride public health and environmental.... Many more ) are widely used such as solid-phase extraction of interference from extracts or size exclusion chromatography and detectors. Is made to identify the nature of the substances that have migrated from the NIST/EPA/NIH mass Spectral Library are derivative of phthalic acid... White solid is an isomer of isophthalic acid and derivatives 1 – 30 1132 and neonatal hypothyroidism solid is isomer! 2 ( R = Me, Ph ) and 1,1′,3,3′-tetraorganodisiloxane-1,3-diols derivatives phthalate esters Alfa. Site ( plus many more ) are available from the plastic material using RSb ( OMe ) (! Completed in developing simulants for migration tests and the corresponding classes derivative of phthalic acid foods 90 % of total matter...

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